Building on the benefits of the SAPIEN 3 platform, now with RESILIA tissue's calcium-blocking technology*2

Calcification is a leading cause of structural valve deterioration (SVD) in aortic tissue valves.1 RESILIA tissue effectively addresses calcification with advanced calcium-blocking.*2

Stable capping blocks calcium from binding to tissue*

*No clinical data are available that evaluate the long-term impact of RESILIA tissue in patients.

See the difference

RESILIA tissue reduced calcification, when compared to traditional surgical valve tissue treatment.

RESILIA tissue features the same tissue technology used in the #1 implanted surgical valve in the U.S.

Delivering the potential to improve valve longevity and reduce reintervention*†

*No clinical data are available that evaluate the long-term impact of RESILIA tissue in patients.
†RESILIA tissue tested against tissue from commercially available bovine pericardial valves from Edwards in a juvenile sheep model. Flameng, et al. J Thorac Cardiovasc Surg 2015;149:340-5.

The only transcatheter heart valve (THV) with dry tissue storage

SAPIEN 3 Ultra valve taller* paravalvular leak (PVL) skirt now available in the 29 mm size

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*Compared to SAPIEN 3 valve

The SAPIEN 3 TAVR fully addresses the vital considerations for lifetime management

In the PARTNER 3 trial, SAPIEN 3 TAVR was proven superior to surgery on the primary endpoint of all-cause death, all stroke, and reshospitilization (valve-related or procedure-related, and including due to heart failure) at one year and multiple prespecified secondary endpoints in low risk patients.

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*No clinical data are available that evaluate the long-term impact of RESILIA tissue in patients.

In a robust clinical trial, surgical valves with RESILIA tissue demonstrated 0% structural valve deterioration (SVD) at 5 years.*3

0%

SVD at 5 years*

0%

reintervention due to calcification

*SVD measured per surgical guidelines as any reintervention

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See the clinical evidence behind RESILIA tissue technology.

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References:   1. Schoen F, et al. Calcification of Tissue Heart Valve Substitutes: Progress Towards Understanding and Prevention. Ann Thorac Surgery 2005 79;1072-80 2. Flameng W, Hermans H, Verbeken E, et al: Randomized assessment of an advanced tissue preservation technology in the juvenile sheep model. J Thorac Cardiovasc Surg. 2015;149(1):340-345. 3. Bavaria JE, Griffith B, Heimansohn DA, et al. Five-year outcomes of the COMMENCE trial investigating aortic valve replacement with RESILIA tissue [published online ahead of print, 2022 Jan 20]. Ann Thorac Surg. 2022;S0003-4975(22)00063-7. doi:10.1016/j.athoracsur.2021.12.058. 4. Mack MJ, Leon MB, Thourani VH, et al. Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients. NEJM. 2019; 380:1695-1705. doi:10.1056/NEJMoa1814052. 5. Nazif TM, Cahill TJ, Daniels D, et al. Real-world experience with the SAPIEN 3 Ultra transcatheter heart valve: a propensity-matched analysis from the United States. Circ Cardiovasc Interv. 2021;14:e010543. doi:10.1161/ CIRCINTERVENTIONS.121.010543. 6. Tarantini G, Nai Fovino L, Le Prince P, et al. Coronary access and percutaneous coronary intervention up to 3 years after transcatheter aortic valve implantation with a balloon-expandable valve. Circ Cardiovasc Interv. 2020;13:e008972. doi:10.1161/CIRCINTERVENTIONS.120.008972.