Dedicated to your pulmonic patients

Edwards Lifesciences is committed to giving more patients less invasive procedures

Your pulmonic patients face a lifetime of invasive surgical procedures, and you are looking for therapy options to lessen the burden. We can get behind that.

That's why the Edwards Alterra adaptive prestent was developed. It allows the SAPIEN 3 valve to reach a broader range of pulmonic patients and potentially delay their need for additional open-heart surgeries.

Continue putting your pulmonic patients first with the SAPIEN 3 valve

A less invasive alternative to surgery that can adapt to your patients' needs

The SAPIEN 3 transcatheter heart valve

Available in 20, 23, 26, and 29 mm

See full indication

The Edwards SAPIEN 3 transcatheter heart valve system with Edwards Commander delivery system is indicated for use in the management of pediatric and adult patients who have a clinical indication for intervention on a dysfunctional right ventricular outflow tract (RVOT) conduit or surgical bioprosthetic valve in the pulmonic position ≥ moderate regurgitation and/or a mean RVOT gradient of ≥ 35 mmHg.

Learn more about the SAPIEN 3 transcatheter heart valve

The SAPIEN 3 transcatheter heart valve with Alterra adaptive prestent

Conforms to the anatomy for placement of a 29 mm SAPIEN 3 valve

See full indication

The Edwards SAPIEN 3 transcatheter pulmonary valve system with Alterra adaptive prestent is indicated for use in the management of pediatric and adult patients with severe pulmonary regurgitation as measured by echocardiography who have a native or surgically-repaired right ventricular outflow tract and are clinically indicated for pulmonary valve replacement.

Learn more about the SAPIEN 3 transcatheter heart valve with the Alterra prestent

A proven transcatheter technology, now available for your pulmonic patients

Potentially delay surgical intervention with a less invasive alternative for patients with a history of pulmonary valve intervention

Excellent Clinical Performance


All cause death at 1 year* (n=51)

Endocarditis at 1 year* (n=51)

Valve frame fracture at 6 months* (n=55)


Delayed surgical intervention (n=56)

Freedom from surgical reintervention at 1 year* (n=56)

Freedom from reintervention with transcatheter heart valve-valve at 1 year* (n=56)


Device success rate*† (n=56)


None/trace paravalvular regurgitation at 1 year* (n=47)

Edwards Sapien3 Ultra Valve Placement

The major risks associated with the transcatheter pulmonic valve procedure include death, heart damage potentially requiring surgery, bleeding, blood vessel complications, and irregular heart beat.

Edwards Commander Delivery

The Commander delivery system brings predictability and control to your pulmonic procedures as well as dual articulation for coaxiality

  • Allows valve positioning and deployment
  • Dual articulation for coaxiality
  • Accurate positioning and deployment
  • Compatible with 14F /16F eSheath
  • Compatible with 24F Gore DrySeal sheath (20, 23, and 26 mm valves) or 26F sheath (29 mm valve)

*COMPASSION S3 trial results using the 20, 23, 26, and 29 mm SAPIEN 3 valve, valve implant population (n=56)
†Device success is a composite of
- Single THV implanted in the desired location
- RV-PA peak-to-peak gradient < 35 mmHg post implantation
- Less than moderate PR by discharge TTE (or earliest evaluable TTE)
- Free of explant at 24 hours post implantation

A less invasive option for more pulmonic patients

Alterra adaptive prestent bridges the gap when pulmonic patients need it most

Delivering excellent clinical outcomes with sustained performance at 2 years1

Precise predictable placement

  • 100% single Alterra prestent deployed in desired location
  • 96.7% single SAPIEN 3 valve deployed in desired location

Excellent outcomes*

  • 0% mortality
  • 0% endocarditis
  • 0% stent fracture requiring reintervention

Sustained performance

  • 1.7% reintervention*
  • 92.5% ≤ mild pulmonary regurgitation**


Trackablity where you want it, recapturability when you need it

With two distinct delivery systems you can focus on optimizing outcomes by further evaluating positioning before valve implantation. Additionally, recapturability of the Alterra adaptive prestent allows you to reposition as needed for precise placement.

Alterra adaptive prestent delivery system

  • Affords the option to recapture and reposition, as needed, for accurate placement
  • Ergonomic design for controlled deployment
  • Designed for smooth tracking to the pulmonic artery
  • Compatible with the 16F eSheath
  • Preloaded prestent

SAPIEN 3 pulmonic delivery system

  • Facilitates SAPIEN 3 valve delivery into Alterra prestent
  • Ability to track to the intended location through vasculature

Explicitly designed for pulmonic therapy, the Edwards SAPIEN 3 transcatheter pulmonary valve system with Alterra adaptive prestent allows you to keep making an impact in the lives of your patients

Procedural animations

SAPIEN 3 Transcather Heart Valve Pulmonic Procedural Animation

Alterra Adaptive Prestent Procedural Animation

Recommended resources

Pulmonic portfolio brochure with sizing guides View now
Alterra Patient Brochure View now

Reach a broader range of pulmonic patients with the Edwards SAPIEN 3 valve and Alterra adaptive prestent

References:   1. Shahanavaz, Shabana. Transcatheter Pulmonary Valve Implantation with the Alterra Adaptive Prestent and SAPIEN 3 Transcatheter Heart Valve: Two-Year Outcomes of the Alterra Pivotal Trial; Presented at PICS-AICS 2023, Washington DC.