The primary endpoint of reduced death, stroke or CV rehospitalisation was maintained over a 2yr follow-up.2See the latest follow-up results
Establishing evidence and informing guidelines for TAVI
PARTNER 3 Trial1
PARTNER 3 — A large randomised, prospective, multi-centre trial showing superior outcomes for transcatheter aortic valve implantation (TAVI) compared to surgery (SAVR) in low-surgical-risk patients.1
The original trial report showed TAVI met both the primary endpoint as well as a number of prespecified secondary endpoints vs SAVR.1Access the original 1yr data
The disease-specific health status improvements for TAVI compared to SAVR were demonstrated not just at 1 month but also at 6 and 12 months.3Read the QoL data
PARTNER II Trial4
PARTNER II Trial showed comparable outcomes for Edwards SAPIEN 3 TAVI vs SAVR in intermediate-risk patients.
Continuing to support TAVI as a viable alternative to SAVR with comparable clinical and durability outcomes
Subsequent subgroup analysis of PARTNER II Trial has provided further insight into the role of TAVI
PARTNER 1A Trial5
TAVI showed similar outcomes compared to SAVR in high surgical risk patients (PARTNER 1A).Read the initial 1yr follow up Find out the subsequent 5yr follow up data
PARTNER 1B Trial6
The first PARTNER Trial. It demonstrated superior clinical outcomes for TAVI vs standard therapy in sAS patients deemed inoperable.Read the initial 1yr follow up Discover the subsequent 5yr follow up
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1. Mack MJ, Leon MB, Thourani VH, et al. Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients. N Engl J Med. 2019;380:1695-1705 (plus Supplementary Appendix).
2. Mack MJ, Leon MB. Two Year Clinical and Echocardiographic Outcomes from the PARTNER 3 Low-Risk Randomised Trial. Presented at ACC.20. Chicago March 2020.
3. Baron SJ, Magnuson EA, Lu M, et al. Health Status after Transcatheter vs. Surgical Aortic Valve Replacement in Patients with Severe Aortic Stenosis at Low Surgical Risk. J Am Coll Cardiol. 2019;74(23):2833-2842.
4. Leon MB, Smith CR, Mack MJ, et al. N Engl J Med. 2016;374:1609–1620 and supplementary material.
5. Smith CR, Leon MB, Mack MJ, et al.; PARTNER Trial Investigators. Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med. 2011;364:2187-98.
6. Leon MB, Smith CR, Mack MJ, et al; PARTNER Trial Investigators. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010;363:1597-607.
For professional use. For a listing of indications, contraindications, precautions, warnings, and potential adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).